Ontology-Based Process Modelling - Will We Live to See It?

Platform process will give platform product - Can we afford it?

Introduction Manufacturing processes for therapeutic monoclonal antibodies (mAbs) have evolved immensely in the past two decades around two major thrust areas. 1) Advancements in a) Cell line developmentbreakthrough and incremental knowledge gain in technology b) Media and feed formulation strategies c) Advent of Disposables and Instrumentation technologies thus offering significant improvement...

Does high folic acid intake affect unrecognized cobalamin deficiency, and how will we know it if we see it?

Twelve years of mandatory food fortification with folic acid (FA), during which widespread self-supplementation pushed FA intake even higher, have nurtured questions about risks to persons with cobalamin deficiency but generated little meaningful data until just recently. In 2007 analysis of National Health and Nutrition Examination Study (NHANES) data linked higher folate concentrations with w...

Colour : How We See It and How We Use It

An Ontology-based Approach to Conceptual Process Modelling

The development of mathematical models for process systems can start from conceptual modelling, which is defined as characterizing the process system to be modelled by physicochemical concepts. The resulting conceptual model serves as a basis to further derive a mathematical model. In this paper, we propose to develop conceptual models using an ontology that represents a conceptualization of pr...

Heterogeneity: we can't live with it, and we can't live without it

As hard as it is to believe now, it was permissible not long ago to sell a prescription drug (in the USA) without providing evidence that it worked; all that was needed was evidence it was safe. Then, KefauvereHarris changed everything. Acting largely in response to the thalidomide tragedy, Estes Kefauver, a senator from Tennessee, and representative Oren Harris from Arkansas introduced the ame...